The monoclonal antibody bevacizumab, which neutralizes vascular endothelial growth factor, significantly affects the migration, survival, and proliferation of cells - all of which are critical for the growth and spread of tumors. The current study`s objective was to create polyurethane structures that are more soluble in water so they may be employed as this active agent`s transmembrane carrier. A polymer drug delivery system was created using an aliphatic isocyanate and a combination of ether and ester polyols, resulting in a suitable release profile and membrane penetrability. The solubility, pH, and refractivity index measurements, the size distribution and surface charge, the encapsulation efficacy and release profile, the proliferation of cells, and skin irritation tests on mice were used to describe the two samples. Our findings reveal that nearly neutral acido-basic polymer structures were achieved, ranging in size from 187 to 423 nm. Zeta potential values suggest a minor alteration in the propensity to form clusters in the sample with increased solubility, and UV-Vis analyses demonstrate an approximately 63±2% encapsulation efficacy. In terms of the samples` biosafety profile, the tests conducted on mouse skin and cell cultures did not result in significant adverse effects at the concentrations that were examined. The results of this preclinical investigation indicate that adding polar groups to polyurethane macromolecular chains improves aqueous solubility without changing the polymer carrier`s other properties.
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The paper presents a parallel between the calculation of deformations for uniaxially compressed rubber spheres, by direct measurement on the experimental stand. Generalities about rubber, definition, properties, main characteristics and examples of use, are presented. An own experimental study is then presented to study the deformability of rubber spherical bodies and to analyze the deviations of rubber behavior from the Hertzian model. An experimental rig was designed for this. Its operation and the working method used, as well as the force-deformation characteristics for different experimental situations are presented, the compression of two or three rubber spheres, with three different ways of supporting them. Considering that a model that accurately describes the behavior of rubber is the Money-Rivlin model, which is characterized by two constants, C10 and C01, these constants were determined by a simple method, using the hardness of the material as a basic element hyperelastic, measured on the Shore A scale. After determining the material constants, the deformation value was determined by numerical modeling with the help of Ansys software. For validation, the experimental curve for the deformation of a rubber sphere on a plane and the numerical curve for the similar situation with the experimentally determined mechanical characteristics, were plotted on the same graph. Finally, the conclusions resulting from the conducted research are presented: - highlighting two ways of evaluating the deformation of rubber spheres experimentally and numerically, determining the Monney-Rivlin specific constants to the material through a simple, efficient and valid method.; - an elegant way to calculate deformations is to model the contact by axisymmetric finite elements, because it uses a minimum number of finite elements and saves significant resources; - both the calculation method and the experimental methods used are validated by a good correspondence between the experimental curve and numerical results.
The paper presents our studies regarding the superior valorization of recycled low-density polyethylene (rLDPE) by compounding with thermoplastic starch (TPS) and ethylene propylene terpolymer elastomer (EPDM). Low-density polyethylene post-consumer waste from foil packaging was used for the experiments. The waste was mechanically recycled and the rLDPE granules obtained were characterized both from a physical-mechanical and structural point of view. In order to obtain new sustainable materials, rLDPE granules were mixed with TPS, EPDM, compatibilizers and crosslinking agents. The mixtures were obtained in a PlastiCorder Brabender mixer at 140°C, 30-80 rpm, working time 7 minutes. The samples made show very good resistance to bending and abrasion, they have very good values of Charpy impact resistance and tear strenght, they show very good behavior to accelerated aging and to the action of some liquids, they have high hardness (51-53) °ShD and a Vicat softening point of 93-96°C. The new materials can be processed by methods specific to plastic materials (extrusion, injection, compression) in order to obtain finished products, and their field of applications can include: the footwear industry, the automotive industry, construction, packaging, agriculture, etc. The LCA analysis of the composites show a low environment impact. The values of the carbon footprint range between 0.58 Kg CO2 eq/kg and 0.75 Kg CO2 eq /kg due to the use of recycle low-density polyethylene and optimised efficient production process.
From the desire to produce environmentally friendly composites, sandwich composites with a matrix made of a Dammar-based hybrid resin, a core of chopped corn cobs, and faces made of natural fabrics were cast and researched in terms of their mechanical properties. The low production cost and the mechanical characteristic values obtained for these sandwich composites have shown that they represent an alternative to MDF, or PAL (Medium Density Fiberboard, or Chipboard). As an application, two elements of a bathroom cabinet were made. The cabinet was exposed to a high-humidity environment, and it was found that the humidity level did not cause any changes in shape or appearance of the elements made from the sandwich composite.
The purpose of the study was the comparison of the contact tightness of the restored proximal area of lateral teeth with celluloid and metallic matrices and a bulk polymer-based biomaterial using an original in vitro assessing method.In 300 plastic right upper molars, mesial and distal vertical boxes (4 mm width in all directions) were prepared. 150 teeth were restored using circumferential celluloid bands and the rest were restored with sectional metallic saddle bands with the same thickness. The mesial/distal contact tightness was measured, before preparations and after restorations using dental floss and an original system consisting in a dynamometer connected to the model fixed on a plate that could slide gravitationally on vertical metallic rails actioned by a mass of 850 g attached with a string. The passing through force was recorded. For the mesial surfaces, the force varied from 4.782 ± 0.014 N (sound) to 5.086 ± 0.011 N (restored) (p < 0.05) for circumferential celluloid matrix while for the sectional metallic matrix, the values varied from 4.787 ± 0.016 N (sound) to 5.596 ± 0.01 N (restored) (p < 0.05). For the distal surfaces, the force varied from 5.589 ± 0.01 N (sound) to 4.777 ± 0.011 N (restored) (p < 0.05) for circumferential celluloid matrix while, for the sectional metallic matrix, the values varied from 5.586 ± 0.012 N (sound) to 5.793 ± 0.015 N (restored) (p < 0.05). Comparing to the sound surfaces, the bulk polymer-based material with high consistency and the circumferential celluloid matrices generated poorer distal and slightly stronger mesial contact area tightness while the sectional metallic ones drove to stronger mesial and distal contacts. However, the celluloid bands are often preferred because they allow the photopolymerization process and permit a good visual control during most of the steps of the working protocol.
Biphasic calcium phosphate (BCP), containing β-tricalcium phosphate and hydroxyapatite, was synthesized by co-precipitation method to obtain a biomimetic artificial bone-like composite using calcium nitrate tetrahydrate [Ca(NO3)∙4H2O] as calcium precursor and ammonium dihydrogen phosphate (NH4H2PO4) as phosphorous precursor, maintaining Ca/P ratio of 1.67. The synthesized biphasic calcium phosphate mixture was dispersed in a sodium alginate (Alg) matrix dissolved in distilled water and lyophilized. The chemical structure, possible interactions between components and morphology of the obtained powder and scaffolds were studied through Fourier transform infrared (FT- IR) spectroscopy, X-ray diffraction (XRD) thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) in order to observe the interactions between BCP and the polymer. The particle size of the powder was also analyzed using the dynamic light scattering (DLS) analysis. Calcined powder had a particle size of 1.8 µm. In addition to the low crystalline hydroxyapatite (HA), as the main phase in the dried samples, β-tricalcium phosphate (β-TCP) was formed after the thermal treatment of 1000˚C as shown by XRD and FT-IR. The obtained composite material presented a highly porous microstructure with interconnected layers where the BCP particles were well dispersed. The micro-structure of the scaffolds was influenced with the change in pore dimensions and rearrangement of the layers due to the incorporation of the BCP particles and by the treatment of the scaffolds with CaCl2.
Hand layup was used to fabricate the glass fibre reinforced aluminium foam epoxy composites in this study. On the manufactured materials, dry sliding wear experiments were performed. The effect of wearprocess parameters such asapplying load (kg), speed (m/s), and sliding distance (m) on specific wear rate (Ws) was investigatedand the obtained results were compared with neat glass fibre reinforced epoxy composite in this work. The outcome of these results showed that specific wear rate (Ws) of glassfibre epoxy composite containing aluminium foam decreased as compared with neat glass fibre reinforced polymer composites. Experimental results showed that a minimum wear rate of 10.1 µm was attained for the sliding velocity (1.5 m/s), Applied load (2 kg), and sliding distance (1000 m) in the fabricated composite laminates. It was observed thatthe resistance to wear in glass fibre reinforced aluminium foam composite was mainly due to the bond strength between aluminium foam and epoxy.
The paper presents a study on the stresses and deformations induced by the transversal loading of some flat plates made of E Glass EWR Fiberglass Woven Roving type, having delamination type defects. The parametric analysis of the delamination influence on the stresses and displacements occurring in the plate material is performed. The results of the static calculation are compared with the experimental tests of the flat plates subjected to bending, highlighting the concordance of the variation of the stresses and displacements versus to the position of the delamination position.
In order to investigate the mechanical properties of polyurethane cement (PUC) composite materials, axial tensile test, acid and alkali corrosion resistance test, bond test with concrete, and bond test with steel bars were conducted. The axial tensile results show that the tensile strength of PUC material is 31.11MPa, the stress-strain curve for axial tensile behavior of the material is obtained through fitting. To explore the durability of PUC materials, acid-alkali-salt corrosion resistance test is carried out, the results show that the PUC material has good resistance to acid and alkali corrosion. The failure mode of the bond test between PUC material and concrete is internal cohesion failure of concrete material, indicating good bond performance of PUC material. Axial tensile test of PUC material is carried out at different temperatures (-40℃~60℃). When subjected to temperatures between 40°C and 60°C, the strength of materials does not deteriorate. However, it is noteworthy that the material’s ability to withstand tensile strain significantly increases as temperatures rise to 60°C. The bonding strength between PUC material and steel bar increases with an increase in protective layer thickness, and at a thickness of 70 mm, the maximum bond stress is achieved at 16.38 MPa. On the other hand, the strength of the bond reduces as the anchorage length increases. Smooth round bars demonstrate a significantly lower bond strength compared to deformed bars, as their maximum bond strength is at approximately 47.4% of that of the deformed bars under the same conditions.
The paper presents the characterization of 5 polymer composite materials with a poly-propylene (PP) matrix obtained with different (mass) concentrations of strontium ferrite (Fe12SrO19) reinforcement that have synergistic protective properties against electrostatic discharges (ESD) and electromagnetic impulses (EMI). These types of composites can be used to protect electronic equipment. To this purpose, suitable polymer composites were developed using SrFe12O19 type filler in two forms (powder and concentrate). The weight ratio of the PP/SrFe12O19 composites obtained by the extrusion process and injection from the melt is 75/25 and 70/30. The characterization of these composite materials consisted of carrying out some physico-chemical tests to determine the hydrostatic density and the resistance to the action of water, as well as FTIR, UV-Vis analyzes and dielectric, magnetic and functional tests to identify the simultaneous protection performance at electromagnetic shielding and electrostatic discharges, which can occur in the electro-technical, electronics and automotive industries. It is also found that all composite materials presented reflection shielding properties (SER) in the range: -71.5 dB...to -56.7 dB, indicating very low absorption shielding. The best performing material was the PP/SrFe12O19 powder composite with a weight ratio of 70/30. At the same time, EDS tests were also carried out on these materials. For these applications, the surface resistance Rs and the point-to-point resistance Rp were tested. Recommended composites for simultaneous EMI and sensitivity to electrostatic discharges (ESD) functionality, in order of their performance, are M2 (with 30% ferrite powder) and M1 (with 25% ferrite powder). M4 composite (with 30% ferrite powder concentrate) can also be used at the limit. Following the research carried out, the obtained results recommend the composite with promising simultaneous operations as M2 (with 30% ferrite powder). The element of originality consists of obtaining polymer composites with simultaneous properties of protection against electromagnetic impulses and electrostatic discharges.