Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study

Pop, Tudor Sorin; Miron, Alina Dia Trambitas; Pop, Anca Maria; Brinzaniuc, Klara; Trambitas, Cristian

Tudor Sorin Pop, Alina Dia Trambitas Miron, Anca Maria Pop, Klara Brinzaniuc, Cristian Trambitas

Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study

Abstract:
Noninvasive techniques, such as Magnetic Resonance Imaging (MRI) are becoming more used in the study of bone regeneration outcomes, in both animal models and human patients. Many studies have shown the potential of tissue engineering therapies to promote healing of skeletal injuries, but further research is needed to optimize these treatment options. This investigation is a continuation of other previous published studies, in which critical-sized bone defects created in the parietal bones of Wistar rats were filled with either bioglass or a biologic collagen scaffold seeded both with adipose-derived mesenchymal stem cells. The present study aims to present the applications of MRI in the assessment of the bone regeneration process in these previously created defects, at specific time intervals. MRI techniques are based on the differences between the spin-latice T1 and spin-spin T2 relaxation times of examined specimens or areas, compared to normal tissues. We measured the relaxation times specific to calvarial specimens with a Brukner Minispec. The results showed that the most favorable results were observed when a collagen scaffold seeded with stem cells was used. MRI enabled the detection of hard and even soft tissue changes, these findings suggesting that MRI could be an effective imaging modality for assessing changes in bone morphology and pathobiology. Furthermore, it can be used as an alternative to Computed Tomography in examining the role of various biomaterials used in bone healing, especially when ionizing radiation is contraindicated.

Keywords:
MRI; animal model; bone regeneration; stem cells; collagen scaffolds

Issue: 2019 Volume 56, Issue 1

Pages: 235-238

Publication date: 2019/3/30

https://doi.org/10.37358/MP.19.1.5158

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
POP, T.S., MIRON, A.D.T., POP, A.M., BRINZANIUC, K., TRAMBITAS, C., Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study, Mater. Plast., 56(1), 2019, 235-238. https://doi.org/10.37358/MP.19.1.5158

Vancouver
Pop TS, Miron ADT, Pop AM, Brinzaniuc K, Trambitas C. Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study. Mater. Plast.[internet]. 2019 Jan;56(1):235-238. Available from: https://doi.org/10.37358/MP.19.1.5158

APA 6th edition
Pop, T.S., Miron, A.D.T., Pop, A.M., Brinzaniuc, K. & Trambitas, C. (2019). Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study. Materiale Plastice, 56(1), 235-238. https://doi.org/10.37358/MP.19.1.5158

Harvard
Pop, T.S., Miron, A.D.T., Pop, A.M., Brinzaniuc, K., Trambitas, C. (2019). 'Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study', Materiale Plastice, 56(1), pp. 235-238. https://doi.org/10.37358/MP.19.1.5158

IEEE
T.S. Pop, A.D.T. Miron, A.M. Pop, K. Brinzaniuc, C. Trambitas, "Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study". Materiale Plastice, vol. 56, no. 1, pp. 235-238, 2019. [online]. https://doi.org/10.37358/MP.19.1.5158

Text
Tudor Sorin Pop, Alina Dia Trambitas Miron, Anca Maria Pop, Klara Brinzaniuc, Cristian Trambitas,
Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study,
Materiale Plastice,
Volume 56, Issue 1,
2019,
Pages 235-238,
ISSN 2668-8220,
https://doi.org/10.37358/MP.19.1.5158.
(https://revmaterialeplastice.ro/Articles.asp?ID=5158)
Keywords: MRI; animal model; bone regeneration; stem cells; collagen scaffolds

RIS
TY - JOUR
T1 - Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study
A1 - Pop, Tudor Sorin
A2 - Miron, Alina Dia Trambitas
A3 - Pop, Anca Maria
A4 - Brinzaniuc, Klara
A5 - Trambitas, Cristian
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2019
VL - 56
IS - 1
SP - 235
EP - 238
UR - https://doi.org/10.37358/MP.19.1.5158
KW - MRI
KW - animal model
KW - bone regeneration
KW - stem cells
KW - collagen scaffolds
ER -

BibTex
@article{MatPlast2019P235,
author = {Pop Tudor Sorin and Miron Alina Dia Trambitas and Pop Anca Maria and Brinzaniuc Klara and Trambitas Cristian},
title = {Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study},
journal = {Materiale Plastice},
volume = {56},
number = {1},
pages = {235-238},
year = {2019},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.19.1.5158},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5158}
}

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