Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier

Borcan, Florin; Soica, Codruta M.; Lazureanu, Voichita; Pinzaru, Iulia A.; Cheveresan, Adelina; Poenaru, Marioara

Florin Borcan, Codruta M. Soica, Voichita Lazureanu, Iulia A. Pinzaru, Adelina Cheveresan, Marioara Poenaru

Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier

Abstract:
Natural mixtures based on bioflavonoids, terpenoids, glycosidic compounds, polyphenols, anthocyanins and essential fatty acids are often more effective and non-toxic than many synthetic drugs. Betulin, a terpene compound with many key-roles in alternative medicine, is almost insoluble in water due to its pentacyclic structure. Different drug carriers are developed to improve the drug efficacy and release. This paper described the evolution of some skin parameters (transepidermal water loss, erythema and stratum corneum hydration) after a short and respectively a long exposure to a polyurethane carrier with and without betulin using sodium lauryl sulfate as reference. It was found that these compounds are safe for human use and the hydratant effect of betulin was reconfirmed.

Keywords:
corneometry; drug delivery system; mexametry; TEWA; triterpenoids; Zeta potential

Issue: 2018 Volume 55, Issue 2

Pages: 149-151

Publication date: 2018/6/30

https://doi.org/10.37358/MP.18.2.4983

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BORCAN, F., SOICA, C.M., LAZUREANU, V., PINZARU, I.A., CHEVERESAN, A., POENARU, M., Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier, Mater. Plast., 55(2), 2018, 149-151. https://doi.org/10.37358/MP.18.2.4983

Vancouver
Borcan F, Soica CM, Lazureanu V, Pinzaru IA, Cheveresan A, Poenaru M. Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier. Mater. Plast.[internet]. 2018 Apr;55(2):149-151. Available from: https://doi.org/10.37358/MP.18.2.4983

APA 6th edition
Borcan, F., Soica, C.M., Lazureanu, V., Pinzaru, I.A., Cheveresan, A. & Poenaru, M. (2018). Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier. Materiale Plastice, 55(2), 149-151. https://doi.org/10.37358/MP.18.2.4983

Harvard
Borcan, F., Soica, C.M., Lazureanu, V., Pinzaru, I.A., Cheveresan, A., Poenaru, M. (2018). 'Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier', Materiale Plastice, 55(2), pp. 149-151. https://doi.org/10.37358/MP.18.2.4983

IEEE
F. Borcan, C.M. Soica, V. Lazureanu, I.A. Pinzaru, A. Cheveresan, M. Poenaru, "Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier". Materiale Plastice, vol. 55, no. 2, pp. 149-151, 2018. [online]. https://doi.org/10.37358/MP.18.2.4983

Text
Florin Borcan, Codruta M. Soica, Voichita Lazureanu, Iulia A. Pinzaru, Adelina Cheveresan, Marioara Poenaru,
Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier,
Materiale Plastice,
Volume 55, Issue 2,
2018,
Pages 149-151,
ISSN 2668-8220,
https://doi.org/10.37358/MP.18.2.4983.
(https://revmaterialeplastice.ro/Articles.asp?ID=4983)
Keywords: corneometry; drug delivery system; mexametry; TEWA; triterpenoids; Zeta potential

RIS
TY - JOUR
T1 - Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier
A1 - Borcan, Florin
A2 - Soica, Codruta M.
A3 - Lazureanu, Voichita
A4 - Pinzaru, Iulia A.
A5 - Cheveresan, Adelina
A6 - Poenaru, Marioara
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2018
VL - 55
IS - 2
SP - 149
EP - 151
UR - https://doi.org/10.37358/MP.18.2.4983
KW - corneometry
KW - drug delivery system
KW - mexametry
KW - TEWA
KW - triterpenoids
KW - Zeta potential
ER -

BibTex
@article{MatPlast2018P149,
author = {Borcan Florin and Soica Codruta M. and Lazureanu Voichita and Pinzaru Iulia A. and Cheveresan Adelina and Poenaru Marioara},
title = {Toxicological Assessment of Betulin Entrapped in a Polyurethane Carrier},
journal = {Materiale Plastice},
volume = {55},
number = {2},
pages = {149-151},
year = {2018},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.18.2.4983},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=4983}
}

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