Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease

Shaat, Fawzia; Pavaloiu, Ramona Daniela; Salceanu, Daniela Crina; Hlevca, Cristina; Nechifor, Gheorghe

Fawzia Shaat, Ramona Daniela Pavaloiu, Daniela Crina Salceanu, Cristina Hlevca, Gheorghe Nechifor

Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease

Abstract:
The main aim of this study was to investigate a mixture of two poorly water-soluble active pharmaceutical ingredients (APIs): an angiotensin II receptor antagonist (valsartan) and a calcium channel blocker (amlodipine besylate), chosen in a fixed-dose, in order to obtain new polymeric nanoparticles (NPs) for cardiovascular diseases treatment. NPs were prepared via nanoprecipitation method using poly (D,L-lactide-co-glycolide) (PLGA) as matrix and Pluronic F127 as stabilizer. Three formulations were investigated with different ratios of AML:VAL:PLGA (1:16:5, 1:16:7.5 and 1:16:10). Particle size, polydispersity index and zeta-potential analyses were performed to characterize and optimize the formulation. The in vitro drug release study was determined by using a dialysis membrane method under sink conditions. All NPs loaded with both APIs showed nano-size, negative potential, a high homogeneity and a slow drugs release in physiological environment.

Keywords:
nanotechnology; cardiovascular; drug release; valsartan; amlodipine; PLGA

Issue: 2018 Volume 55, Issue 3

Pages: 299-302

Publication date: 2018/9/30

https://doi.org/10.37358/MP.18.3.5017

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SHAAT, F., PAVALOIU, R.D., SALCEANU, D.C., HLEVCA, C., NECHIFOR, G., Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease, Mater. Plast., 55(3), 2018, 299-302. https://doi.org/10.37358/MP.18.3.5017

Vancouver
Shaat F, Pavaloiu RD, Salceanu DC, Hlevca C, Nechifor G. Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease. Mater. Plast.[internet]. 2018 Jul;55(3):299-302. Available from: https://doi.org/10.37358/MP.18.3.5017

APA 6th edition
Shaat, F., Pavaloiu, R.D., Salceanu, D.C., Hlevca, C. & Nechifor, G. (2018). Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease. Materiale Plastice, 55(3), 299-302. https://doi.org/10.37358/MP.18.3.5017

Harvard
Shaat, F., Pavaloiu, R.D., Salceanu, D.C., Hlevca, C., Nechifor, G. (2018). 'Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease', Materiale Plastice, 55(3), pp. 299-302. https://doi.org/10.37358/MP.18.3.5017

IEEE
F. Shaat, R.D. Pavaloiu, D.C. Salceanu, C. Hlevca, G. Nechifor, "Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease". Materiale Plastice, vol. 55, no. 3, pp. 299-302, 2018. [online]. https://doi.org/10.37358/MP.18.3.5017

Text
Fawzia Shaat, Ramona Daniela Pavaloiu, Daniela Crina Salceanu, Cristina Hlevca, Gheorghe Nechifor,
Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease,
Materiale Plastice,
Volume 55, Issue 3,
2018,
Pages 299-302,
ISSN 2668-8220,
https://doi.org/10.37358/MP.18.3.5017.
(https://revmaterialeplastice.ro/Articles.asp?ID=5017)
Keywords: nanotechnology; cardiovascular; drug release; valsartan; amlodipine; PLGA

RIS
TY - JOUR
T1 - Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease
A1 - Shaat, Fawzia
A2 - Pavaloiu, Ramona Daniela
A3 - Salceanu, Daniela Crina
A4 - Hlevca, Cristina
A5 - Nechifor, Gheorghe
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2018
VL - 55
IS - 3
SP - 299
EP - 302
UR - https://doi.org/10.37358/MP.18.3.5017
KW - nanotechnology
KW - cardiovascular
KW - drug release
KW - valsartan
KW - amlodipine
KW - PLGA
ER -

BibTex
@article{MatPlast2018P299,
author = {Shaat Fawzia and Pavaloiu Ramona Daniela and Salceanu Daniela Crina and Hlevca Cristina and Nechifor Gheorghe},
title = {Evaluation of AML-VAL Nanoparticles as Combined Therapy in Cardiovascular Disease},
journal = {Materiale Plastice},
volume = {55},
number = {3},
pages = {299-302},
year = {2018},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.18.3.5017},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5017}
}

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